Abdelsayed, Michael Moris
Assistant Professor
Faculty - Biology
Brief Biography
Visit our website: www.rnatherm.com
RNA thermometers are highly structured noncoding RNAs located in the 5′-untranslated regions (UTRs) of genes that regulate expression by undergoing conformational changes in response to temperature. Typically, gene expression is induced at higher temperatures as the RNA denatures and reveals the ribosome binding site for a downstream gene. We developed Robo-Therm, a pipeline that combines an adaptive and user-friendly in silico motif search with a well-established reporter system to identify and characterize RNA thermometers.
We have successfully implemented Robo-Therm to discover and characterize eight novel RNA thermometers (see research blog for me). All of these annotated RNA thermometers have been found in bacteria genomes, and two of them also occur in phage genomes which infect the bacterial host that also contains the same thermometer.
Ongoing research is focused on discovering more RNA thermometers, identifying new thermoregulatory RNA elements, and engineering synthetic RNA thermometers.
Research
This person has not added any Research Interests.
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